1P-LSD

1P-LSD
Molecular structure of 1P-LSD
Chemical Nomenclature
Common names	1P-LSD
Substitutive name	1-propionyl-lysergic acid diethylamide
Systematic name	N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Class Membership
Psychoactive class	Psychedelic
Chemical class	Lysergamide
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 10 - 25 µg Light 25 - 75 µg Common 75 - 150 µg Strong 150 - 300 µg Heavy 300 µg + Duration Total 8 - 12 hours Onset 20 - 60 minutes Come up 45 - 120 minutes Peak 3 - 5 hours Offset 3 - 5 hours After effects 6 - 24 hours

Summary sheet: 1P-LSD

1-propionyl-lysergic acid diethylamide (abbreviated 1P-LSD) is a semi-synthetic psychedelic substance of the lysergamide family.

This substance has little to no history of human use. It has gained some popularity over the last few years but continues to remain legal in most parts of the world as an ambiguously legal substitute for LSD (see: designer drug). Its structural similarity to LSD and ALD-52 suggest an extremely similar effect profile. Due to the lack of research relating to this substance, all discussion relating to its pharmacology is purely based on its structure and subjective effect similarities to LSD and other designer lysergamides.

Over the first few months of 2015, 1P-LSD began to be marketed as a legal alternative to LSD through online research chemical vendors which are currently selling the compound in the form of easily accessible blotter sheet tabs. It is typically marketed as a research chemical, which means that it is sold legally for scientific and research purposes but is not intended for human consumption.

Chemistry

1P-LSD is a molecule of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH₃CH₂CO- bound to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to CH₃CO- instead of the propionyl group bound to the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.

Pharmacology

Main article: Serotonergic psychedelic

1P-LSD likely acts as a 5-HT_2A partial agonist. The psychedelic effects are thought to come from 1P-LSD's efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to be elusive.

It has been theorized that 1P-LSD may be a prodrug of LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum, meaning 1P-LSD not only acts as a prodrug for LSD but is also directly acting as a serotonin receptor agonist in its own right.

Prior to the publishing of the above cited research, pharmacologist David E. Nichols reportedly commented with his thoughts on 1P-LSD serotonin receptor binding:

I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. The way that LSD docks into the 5-HT_2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor.

Subjective effects

The effects of 1P-LSD are essentially the same to that of its close structural relative LSD with the differences being so minuscule that they are almost negligible and essentially virtually indistinguishable from one another. In comparison to other psychedelics such as psilocin, LSA and ayahuasca, 1P-LSD is significantly more stimulating and fast-paced regarding the specific style of its physical and cognitive effects.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects

• Spontaneous tactile sensations - The "body high" of 1P-LSD can be characterized as proportionally very intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location specific tingling sensation. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of 1P-LSD, this sensation will usually hit its highest level and become so overwhelming that people may find themselves writhing on the floor in complete pleasure.
• Nausea - Mild nausea is occasionally reported when consumed in moderate to high doses and either passes instantly once the tripper has vomited or gradually fades by itself as the peak sets in.
• Tactile enhancement
• Bodily control enhancement
• Increased heart rate
• Pupil dilation
• Muscle spasms
• Stimulation - Regarding its effects on the physical energy levels of the tripper, 1P-LSD is usually regarded as very energetic and stimulating without being forced. For example, when it is taken in any environment, it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin are sedating and relaxed.

Cognitive effects

• Analysis enhancement
• Anxiety
• Conceptual thinking
• Creativity enhancement
• Delusions
• Emotion enhancement
• Feelings of interdependent opposites
• Feelings of self-design
• Immersion enhancement
• Increased music appreciation
• Memory suppression
  • Ego death
• Mindfulness
• Novelty enhancement
• Personal bias suppression
• Spirituality enhancement
• Thought acceleration
• Thought disorganization
• Thought loops
• Time distortion
• Unity and interconnectedness
• Wakefulness

Visual effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Distortions

• Colour shifting
• Depth perception distortions
• Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as highly detailed and cartoon-like in its appearance. The distortions are slow and smooth in motion and fleeting in appearance.
• Perspective distortions
• Symmetrical texture repetition
• Tracers

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 2C-B or 2C-I than psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, synthetic in feel, multicoloured in scheme, flat in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in its corners, non-immersive in-depth and consistent in intensity.

In the case of higher level geometry, this substance is level 8A dominant but is also capable of inducing 8B Geometry under the right circumstances.

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - Although 1P-LSD is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, these effects are incredibly rare and inconsistent in comparison. While traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 1P-LSD will for most simply go straight into Level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, LSD is simply not as deep of an experience as certain other psychedelics. On the rare occasion that they are induced, however, they can be comprehensively described in terms of their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability and geometry-based in appearance.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

• Experience:1P-LSD: 100ug, A Fear and loathing into Bliss
• Experience:300mg 1P-LSD + 40mg diphenidine - My first psychotic break
• Experience:Finding myself within the forest

Additional experience reports can be found here:

• Erowid Experience Vaults: 1P-LSD

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 1P-LSD use do not appear to have been studied in any scientific context and the exact toxic dose is unknown. This is because 1P-LSD is a research chemical with very little history of human use. Anecdotal evidence from people within the psychonaut community who have tried 1P-LSD suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one uses harm reduction practices when using this drug.

Tolerance and addiction potential

1P-LSD is not habit-forming and the desire to use it can actually decrease with use. It is mostly self-regulating.

Tolerance to the effects of 1P-LSD are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 1P-LSD presents cross-tolerance with all psychedelics, meaning that after the use of 1P-LSD all psychedelics will have a reduced effect.

Legal issues

1P-LSD is currently a gray area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries, but people may still be charged for its possession under certain circumstances such as under analog laws and with the intent to sell or consume.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• United States - Since 1P-LSD is theorized to be a prodrug of LSD, it would likely be illegal in the United States under the Federal Analogue Act.
• Switzerland - 1P-LSD is illegal in Switzerland as of December 2015.
• Latvia - 1P-LSD is illegal in Latvia. Although it is not officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1st, 2015.
• Sweden - Following its sale as a designer drug, 1P-LSD was made illegal in Sweden on 26 January 2016.
• Germany - 1P-LSD is not listed under their controlled substance act.

See also

• Responsible use
• Research chemical
• Lysergamide
• Psychedelic
• LSD
• ALD-52
• AL-LAD
• ETH-LAD
• LSZ

External links

• 1P-LSD (Wikipedia)
• 1P-LSD (Tripsit)
• 1P-LSD (Bluelight)