Phenethylamine

Substitutive structure of a phenethylamine molecule.

Substituted phenethylamine refers to a class of compounds which typically produce strong psychedelic effects.

Chemistry

Phenethylamine comprises a benzene ring attached to a mono-amine group via an ethyl side-chain.

Hydrogen atoms around the structure can be substituted for other functional groups to produce drugs of varying potency, affinity, efficacy and half-life.

Pharmacology

Main article: Serotonergic psychedelic

The psychedelic effects of tryptamines are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Several neurotransmitters are derived from phenethylamine, such as:

• Adrenaline
• Dopamine
• Noradrenaline

Substitutions

List

• 25B-NBOMe
• 25C-NBOMe
• 25I-NBOMe
• 25N-NBOMe
• 2C-B
• 2C-C
• 2C-E

• 2C-I
• 2C-P
• 2C-T-2
• 2C-T-7
• DOB
• DOC
• DOM

Table

From Isomerdesign

	RN	Rα	Rβ	R2	R3	R4	R5	R6
25B-NBOMe	CH₂-C₆H₄-OCH₃				OCH₃	Br		OCH₃
25C-NBOMe	CH₂-C₆H₄-OCH₃				OCH₃	Cl		OCH₃
25I-NBOMe	CH₂-C₆H₄-OCH₃				OCH₃	I		OCH₃
25N-NBOMe
2C-B					OCH₃	Br		OCH₃
2C-C
2C-E					OCH₃	CH₂-CH₃		OCH₃
2C-I					OCH₃	I		OCH₃
2C-P					OCH₃	CH₂-CH₃-CH₃		OCH₃
2C-T-2					OCH₃	S-CH₂-CH₂-CH₃		OCH₃
2C-T-7					OCH₃	S-CH₂-CH₂-CH₃		OCH₃
DOB		CH₃			OCH₃	Br		OCH₃
DOC		CH₃			OCH₃	Cl		OCH₃
DOM		CH₃			OCH₃	CH₃		OCH₃

See also

• Phenethylamine (Wikipedia)

References

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